Wen-Chuan Lina* and Chang-Chi Hsiehb

a Department of Pharmacology
b Institute of Integrated Chinese Western Medicine, China Medical University, 91 Hsueh Shih Road, Taichung, Taiwan

 

Download Citation: |
Download PDF


ABSTRACT

Anoectochilus formosanus is an important ethnomedicinal plant of Taiwan. We investigated the effect of oral administration of A. formosanus effective fraction (AFEF) on the innate immune response in mice. Male BALB/c mice were treated orally for 2 weeks with 500, 1000 and 1500 mg/kg of AFEF. Primary peritoneal macrophage harvest from mice that administered with AFEF (500 –1500 mg/kg) was directed to activate phagocytosis. AFEF significantly increased interferon-production from lymph node cells by ConA stimulation for 48 hours in AFEF (1500 mg/kg) treated group. AFEF might be the active fraction in activation of innate immunity.


Keywords: Anoectochilus formosanus; immunomodulation; allergy.


Share this article with your colleagues

 


REFERENCES

  1. [1] Alsam, S., Sissons, J., Dudley, R. and Khan, N.-A. 2005. Mechanisms associated with Acanthamoeba castellanii (T4) phagocytosis. Parasitology Research, 96: 402-409.

  2. [2] Corradin, S.-B., Buchmuller-Rouiller, Y.-B. and Mauel, J. 1991. Phagocytosis enhances murine macrophages activation by interferon-and tumor necrosis factor-. European Journal of Immunology, 21: 2553-2558.

  3. [3] Kan, W.-S. 1979. Pharmaceutical Botany. National research Institute of Chinese Medicine, Taiwan, ROC.

  4. [4] Liou, C.-J., Li, M.-L. and Tseng, J. 2004. Intraperitoneal injection of ginseng extract enhances both immunoglobulin and cytokine production in mice. American Journal of Chinese Medicine, 32: 75-88.

  5. [5] Pinello, K.-C, Fonseca, E.-S.-M., Akisue, G., Silva, A.-P., Oloris, S.-C.-S., Sakai, M., Matsuzaki, P., Nagamine, M.-K., Neto, J.-P. and Dagli, M.-L.-Z. 2005. Effects of Pfaffia paniculata (brazilian ginseng) extract on macrophage activity. Life Sciences.

  6. [6] Shih, C.-C., Wu, Y.-W. and Lin, W.-C. 2005. Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats. Phytomedicine, 12: 453-460.

  7. [7] Shih, C.-C., Wu, Y.-W., Hsieh, C.-C. and Lin, W.-C. 2004. Effect of Anoectochilus formosanus on fibrosis and regeneration of the liver in rats. Clinical and Experimental Pharmacology and Physiology, 31: 620-625.


ARTICLE INFORMATION



Accepted: 2005-12-04
Available Online: 2005-12-13


Cite this article:

Lin, W.-C., Hsieh, C.-C. 2005. Commercial application of anoectochilus formosanus: Immunomodulating Activities. International Journal of Applied Science and Engineering, 3, 175–178. https://doi.org/10.6703/IJASE.2005.3(3).175

Other people also read ...