International Journal of Applied Science and Engineering

Published by Chaoyang University of Technology

Valarmathy Ramaswamy1,2, Sampath Krishnan3, Jayabalakrishnan Chinnasamy4*, Tamiloli Devendhiran5, Mei-Ching Lin5

1 Research and Development Center, Bharathiar University, Tamil Nadu, India
2 Department of Chemistry, Hindustan College of Engineering and Technology, Tamil Nadu, India
3 Department of Chemistry, Kumaraguru College of Technology, Tamil Nadu, India
4 PPG College of Arts and Science, Tamil Nadu, India
5 Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan, R.O.C.


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Ru(II)BT have been synthesized by the reaction between substituted bromobenzal thiosemicarbazones and precursors of ruthenium metal complexes, [RuHCl(CO)(EPh3)3] (where E = P/As). The bromobenzal thiosemicarbazones and Ru(II)BT was characterized by analytical and spectroscopic techniques. It confirms the coordination of the thiosemicarbazone ligands and suggest the octahedral geometry of the complexes. The Ru(II)BT is comprised of a metal centre with bidentate ligands. The stabilization of free radicals with Ru(II)BT was studied. The ligand and Ru(II)BT have significant anticancer activity on MCF-7 cancer cells.

Keywords: Ru(II), Anticancer, Antioxidant, Bromobenzal thiosemicarbazones.

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Received: 2020-10-18
Revised: 2021-03-18
Accepted: 2021-04-29
Publication Date: 2021-09-01

Cite this article:

Ramaswamy, V., Krishnan, S., Jayabalakrishnan, C., Devendhiran, T., Lin, M.-C. 2021. Bromobenzal thiosemicarbazones of ruthenium(II) complexes: Synthesis and bio applications. International Journal of Applied Science and Engineering, 18, 2020246.

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